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Published in vivo studies have indicated that elevated Ggt1 activity along with cellular glutathione depletion are associated with the increased oxidative stress induced by estrogen deficiency under ovariectomy or menopause conditions ( Third, based on the data presented in this paper, HPL exhibited the potential to restore Anpep expression in the glutathione metabolism pathway and turnover-induced metabolite shift, which reflect the powerful effect of HPL on glutathione redox stress

Exchanged material was stored at 20 C until use

The uridylyl transferase TUT7-mediated accumulation of exosomal miR-1246 reprograms TAMs to support CRC progression